A plague know as shackles is sweeping through Nightholme. One of the symptons of the plague are caffed wrist as though one has been in shackles for a longe time. The city leaders have, for the most part, done a good job of containing the spread of the disease. Their first step was to increase security, with screenings at either end of the Vein. Those found infected are quarantined, then shipped down-river in plague-ships. The result is that the marshes surrounding south of the city have sprouted plague colonies.